Although my knowledge of life in Canada is limited to the stereotypes of Mounties chasing bad guys and the people’s love of ice hockey, I did see that their Therapeutic Products Directorate (TPD) (the Canadian equivalent of the FDA) has given a nod of approval to expanding the use of the once-daily version of tramadol. To date, it has only been indicated for the treatment of moderate pain. Now the TPD has accepted new evidence of its appropriateness in the treatment of moderately severe pain. (more…)